Minoryx Therapeutics announces that it has successfully completed its phase 1 trial with MIN-102. MIN-102 targets X-linked adrenoleukodystrophy (X-ALD), a rare and chronically debilitating life threatening neurodegenerative disease. There are two main clinical phenotypes of X-ALD: adrenomyeloneuropathy (AMN), characterized by progressive motor dysfunction, and inflammatory cerebral ALD (cALD), characterized by severe neuroinflammation leading to early death. There are currently no pharmacological treatments for X-ALD. MIN-102 is the only product in development for potential use across all the main phenotypes.

The phase 1 trial was a combined single- and multiple-ascending dose study with the aim of assessing pharmacokinetics, safety and tolerability of MIN-102 in healthy male volunteers. Additionally, the trial included assessment of food effect, evaluation of brain penetration and biomarkers for PPAR Gamma engagement. Based on the successful completion of the phase 1 trial, a phase 2/3 trial in adult AMN patients will be launched in the coming months.

You can extend this information to the website Minoryx Therapeutics.

Photo: Dr. Marc Martinell, CEO of Minoryx Therapeutics. © Minoryx